Eclipse Phase.

The new tabletop RPG Eclipse Phase takes place in a future altered by a Singularity 'Gone Wrong'. The only humans left were ones who escaped the cataclysm on Earth by scanning their brains and beaming them to other points in the Solar System. The resulting distopia is an attempt to do Hard-SF Horror in set in a situation that one can fear might actually come about.

There is a review by Anders Sandberg on his blog, and he seems quite enthusiastic about it, which is enough of an endorsement for me. I've collaborated (in a small way) with Anders on game stuff in the past, so I know that if he likes something, I am likely to like it too.